-----2006-----
Dixon AM, Stanley BJ, Matthews EE, Dawson JP, Engelman DM"Invariant Chain Transmembrane Domain Trimerization: A Step in MHC Class II Assembly."
Biochemistry (2006) 45, 5228-34
[Abstract ] [
PDF reprint]
Miyauchi, K., Curran, R., Matthews, E., Komano, J., Hoshino, T.,Engelman, D. M., Matsuda, Z.
"Mutations of Conserved Glycine Residues within the Me mbrane-Spanning Domain of Human Immunodeficiency Virus Type 1 gp41 Can Inhibit M embrane Fusion and Incorporation of Env onto Virions."
Jpn J Infect Dis. (2006) 59, 77-84
[Abstract ] [
PDF reprint]
Sachs JN, Engelman DM
"Introduction to the Membrane Protein Reviews: The Int erplay of Structure, Dynamics, and Environment in Membrane Protein Function"
Annu Rev Biochem. (2006) 75, 707-12
[Abstract ] [
PDF reprint]
Finger, C., Volkmer, T., Prodohl, A., Otzen, D. E., Engelman, D. M., Schneider, D.
"The Stability of Transmembrane Helix Interactions Mea sured in a Biological Membrane"
J. Mol. Bio. (2006) 358, 1221-8
[Abstract ] [
PDF reprint]
Reshetnyak, Y. K., Andreev, O. A., Lehnert, U., Engelman, D. M.
"Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix"
PNAS (2006) 103, 6460-65
[Abstract ] [
PDF reprint]
-----2005-----
Engelman, DM"Membranes are more mosaic than fluid"
Nature (2005) 438, 578-80
[Abstract] [
PDF reprint]
Chin CN, Sachs JN, Engelman DM
"Transmembrane homodimerization of receptor-like prote in tyrosine phosphatases."
FEBS Lett. (2005) 579(17), 3855-8
[Abstract] [
PDF reprint]
Alexandrov V, Lehnert U, Echols N, Milburn D, Engelman D, Gerstein M
"Normal modes for predicting protein motions: a compre hensive database assessment and associated Web tool."
Protein Sci. (2005) 14(3), 633-43
[Abstract] [
PDF reprint]
Freeman-Cook LL, Edwards AP, Dixon AM, Yates KE, Ely L, Engelman DM, Dimaio D
"Specific locations of hydrophilic amino acids in cons tructed transmembrane ligands of the platelet-derived growth factor beta recepto r."
J Mol Biol. (2005) 345(4), 907-21
[Abstract] [
PDF reprint]
-----2004-----
Lehnert, U., Xia, Y., Royce, T. E., Goh, C.-S., Liu, Y, Senes, A., Yu, H., Zhang
, Z., Engelman, D. M., Gerstein, M"Computational analysis of membrane proteins: genomic occurrence, structure prediction and helix interactions."
Quart. Rev. Biophys. (2004) 37(2), 121-146
[
PDF reprint]
Schneider D, Engelman DM
"Motifs of two small residues can assist but are not s ufficient to mediate transmembrane helix interactions."
J Mol Biol. (2004) 343(4), 799-804
[Abstract] [
PDF reprint]
R Braun, DM Engelman, K Schulten
"Molecular Dynamics Simulations of Micelle Formation a round Dimeric Glycophorin A Transmembrane Helices."
Biophys J. (2004) 87(2), 754-63
[Abstract] [
PDF reprint]
RA Melnyk, S Kim, AR Curran, DM Engelman, JU Bowie, CM Deber
"The affinity of GXXXG motifs in transmembrane helix-h elix interactions is modulated by long-range communication."
J.Biol.Chem. (2004) 279 (16),16591-7
[Abstract] [
PDF reprint]
LL Freeman-Cook, AM Dixon, JB Frank, Y Xia, L Ely, M Gerstein, DM Engelman, D Di Maio
"Selection and Characterization of Small Random Transm embrane Proteins that Bind and Activate the Platelet-derived Growth Factor beta Receptor."
J. Mol. Biol. (2004) 338(5), 907-20
[Abstract] [
PDF reprint]
K Mitra, I Ubarretxena-Belandia, T Taguchi, G Warren, DM Engelman
"Modulation of the bilayer thickness of exocytic pathw ay membranes by membrane proteins rather than cholesterol."
PNAS (2004) 101(12), 4083-8
[Abstract] [
PDF reprint]
Y. Liu, M. Gerstein, DM. Engelman
"Transmembrane protein domains rarely use covalent dom ain recombination as an evolutionary mechanism"
PNAS (2004) 101, 3495-3497
[Abstract] [
PDF reprint]
D Schneider, DM Engelman
"Involvement of transmembrane domain interactions in si gnal transduction by a/b integrins."
J. Biol. Chem. (2004), 279(11), 9840-9846
[Abstract] [
PDF reprint]
-----2003-----
DM Engelman, Y Chen, CN Chin, R Curran, AM Dixon, A Dupuy, A Lee, U Lehnert, E M
athews, Y Reshetnyak, A Senes, J-L Popot"Membrane Protein Folding: Beyond the Two Stage Model"
FEBS Lett. (2003), 555, 122-5
[Abstract] [
PDF reprint]
LE Fisher, DM Engelman, JN Sturgis
"Effect of detergents on the association of the glycoph orin a transmembrane helix."
Biophys. J. (2003), 85(5), 3097-105
[Abstract] [
PDF reprint]
SN Constantinescu, T Keren, WP Russ, I Ubarretxena-Belandia, Y Malka, KF Kubatzk y, DM Engelman, HF Lodish, YI Henis
"The epo receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins."
J. Biol. Chem. (2003), 278(44), 43755-63
[Abstract] [
PDF reprint]
AR Curran and DM Engelman
"Sequence motifs, polar interactions and conformational changes in helical membrane proteins."
Curr.Opin.Struct.Biol (2003), 13, 412-7
[Abstract] [
PDF reprint]
JP Dawson, RA Melnyk, CM Deber and DM Engelman
"Sequence context strongly modulates association of pol ar residues in transmembrane helices"
J Biol Chem (2003), 331, 255-62
[Abstract] [
PDF reprint]
J.-L. Popot, E. A. Berry, D.Charvolin, C.Creuzenet, C.Ebel, D.M.Engelman, M.Flönmeyer, F. Giusti, Y. Gohon, P.HervéQ.Hong, J.H.Lakey, K.Leonard, H.A.Shuman, P.Timmin s, D. E. Warschawski, F.Zito, M.Zoonens, B.Pucci and C. Tribet
"Amphipols: polymeric surfactants for membrane biology research."
Cell. Mol. Life Sci. (2003), 60, 1-16
[Abstract] [
PDF reprint]
DM Engelman
"Electrostatic fasteners hold the T cell receptor-CD3 c omplex together."
Mol. Cell (2003), 11, 5-6
[Abstract] [
PDF reprint]
D Schneider, DM Engelman
"GALLEX: a measurement of heterologous association of t ransmembrane helices in a biological membrane"
J Biol Chem (2003), 278, 3105-11
[Abstract] [
PDF reprint]
-----2002-----
D Schneider, Y Liu, M Gerstein and DM Engelman"Thermostability of membrane protein helix-helix intera ction elucidated by statistical analysis"
FEBS Lett (2002), 532(1-2), 231-6
[Abstract] [
PDF reprint]
Bowen ME, DM Engelman and AT Brunger
"Mutational analysis of Synaptobrevin Trasmembrane Doma in Oligomerization"
Biochemistry (2002), 41, 15861-6
[Abstract] [
PDF reprint]
Y Liu, DM Engelman and M Gerstein
"Genomic analysis of membrane protein families: abundan ce and conserved motifs"
Genome Biology (2002), 3(10):research0054
[Abstract] [
PDF reprint]
K Mitra, TA Steitz and DM Engelman
"Rational design of'water-soluble' bacteriorhodopsin va riants"
Prot. Eng. (2002), 15, 485-492
[Abstract] [
PDF reprint]
JP Dawson, JS Weinger and DM Engelman
"Motifs of serine and threonine can drive association o f transmembrane helices"
J.Mol.Biol. (2002), 316, 799-805
[Abstract] [
PDF reprint]
-----2001-----
KG Fleming and DM Engelman"Specificity in transmembrane helix-helix interactions can define a hierarchy of stability for sequence variants"
PNAS (2001), 98, 14340-14344
[Abstract] [
PDF reprint]
KG Fleming and DM Engelman
"Computation and mutagenesis suggest a right-handed str ucture for the synaptobrevin transmembrane domain"
Proteins (2001), 45, 313-317
[Abstract] [
PDF reprint]
JA Leeds, D Boyd, DR Huber, GK Sonoda, HT Luu, DM Engelman, J Beckwith
"Genetic selection for and molecular dynamic modeling o f a protein transmembrane domain multimerization motif from a random Escheric hia coli genomic library"
J.Mol.Biol (2001), 313, 181-195
[Abstract] [
PDF reprint]
A. Senes, I Ubarretxena-Belandia and DM Engelman
"The Ca-H···O hydrogen bond as a determinant of stability and specificity in transmembrane helix interaction s"
PNAS (2001), 98, 9056-61
[Abstract] [
PDF reprint]
I Ubarretxena-Belandia and DM Engelman
"Helical membrane proteins: diversity of functions in t he context of simple architecture"
Current Opinion Struct. Biol. (2001), 11, 370-6
[Abstract] [
PDF reprint]
H Li, MJ Cocco, TA Steitz and DM Engelman
"Conversion of phospholamban into a soluble pentameric helical bundle"
Biochemistry (2001), 40, 6636-40
[Abstract] [
PDF preprint]
LE Fisher and DM Engelman
"High yield synthesis and purification of an alpha-heli cal transmembrane domain"
Anal. Biochem. (2001), 293, 102-8
[Abstract] [
PDF preprint]
FX Zhou, HJ Merianos, AT Brunger and DM Engelman
"Polar residues drive association of polyleucine transm embrane helices"
PNAS (2001), 98(5), 2250-2255
[Abstract] [
PDF reprint]
-----2000-----
HI Petrache, A Grossfield, KR MacKenzie, DM Engelman and TB Woolf"Modulation of Glycophorin A Transmembrane Helix Intera ctions by Lipid Bilayers: Molecular Dynamics Calculations."
J. Mol. Biol. (2000), 302(3), 727-746
[Abstract] [
PDF reprint]
J-L Popot and DM Engelman
"Helical membrane protein folding, stability, and evolu tion"
Annu. Rev. Biochem. (2000), 69, 881-922
[Abstract] [
PDF reprint]
Z Bu, DA Neumann, SH Lee, CM Brown, DM Engelman and CC Han
"A View of Dynamics Changes in the Molten Globule-Nativ e Folding Step by Quasielastic Neutron Scattering"
J.Mol.Biol. (2000), 301(2), 525-36
[Abstract] [
PDF reprint]
FX Zhou, MJ Cocco, WP Russ, AT Brunger and DM Engelman
"Interhelical Hydrogen Bonding Drives Strong Interactio ns in Membrane Proteins"
Nature Struct. Biol. (2000) 7(2), 154-60
[Abstract] [
PDF reprint]
WP Russ and DM Engelman
"The GxxxG motif: a framework for transmembrane helix-h elix association"
J.Mol.Biol. (2000), 296(3), 911-9
[Abstract] [
PDF reprint]
A Senes, M Gerstein and DM Engelman
"Statistical analysis of amino acid patterns in transme mbrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions"
J.Mol.Biol. (2000) 296(3), 921-36
[Abstract] [
PDF reprint]
[Suplementary material]
S Koide, X Huang, K Link, A Koide, Z Bu and DM Engelman
"Design of single-layer beta-sheets without a hydrophob ic core"
Nature (2000) 403, 456-60
[Abstract] [
PDF reprint]
-----1999-----
LE Fisher, DM Engelman and JN Sturgis"Detergents Modulate Dimerization, but not Helicity, of the Glycophorin A Transmembrane Domain"
J.Mol.Biol. (1999) 293(3), 639-51
[Abstract] [
PDF reprint]
JA McNew, T Weber, DM Engelman, TH Sollner and JE Rothman
"The length of the flexible SNAREpin juxtamembrane regi on is a critical determinant of SNARE-dependent fusion."
Mol. Cell (1999) 4(3), 415-21
[Abstract] [
PDF reprint]
Z Bu and DM Engelman
"A method for determining transmembrane helix associati on and orientation in detergent micelles using small angle X-ray scattering"
Biophys. J. (1999) 77(2), 1064-73
[Abstract] [
PDF reprint]
C Schubert, JA Hirsch, VV Gurevich, DM Engelman, PB Sigler and KG Fleming
"Visual arrestin activity may be regulated by self-assoNature (2000) 403, 456-60
[Abstract] [
PDF reprint]
-----1999-----
LE Fisher, DM Engelman and JN Sturgis"Detergents Modulate Dimerization, but not Helicity, of the Glycophorin A Transmembrane Domain"
J.Mol.Biol. (1999) 293(3), 639-51
[Abstract] [
PDF reprint]
JA McNew, T Weber, DM Engelman, TH Sollner and JE Rothman
"The length of the flexible SNAREpin juxtamembrane regi on is a critical determinant of SNARE-dependent fusion."
Mol. Cell (1999) 4(3), 415-21
[Abstract] [
PDF reprint]
Z Bu and DM Engelman
"A method for determining transmembrane helix associati on and orientation in detergent micelles using small angle X-ray scattering"
Biophys. J. (1999) 77(2), 1064-73
[Abstract] [
PDF reprint]
C Schubert, JA Hirsch, VV Gurevich, DM Engelman, PB Sigler and KG Fleming
"Visual arrestin activity may be regulated by self-assoNature (2000) 403, 456-60
[Abstract] [
PDF reprint]
-----1999-----
LE Fisher, DM Engelman and JN Sturgis"Detergents Modulate Dimerization, but not Helicity, of the Glycophorin A Transmembrane Domain"
J.Mol.Biol. (1999) 293(3), 639-51
[Abstract] [
PDF reprint]
JA McNew, T Weber, DM Engelman, TH Sollner and JE Rothman
"The length of the flexible SNAREpin juxtamembrane regi on is a critical determinant of SNARE-dependent fusion."
Mol. Cell (1999) 4(3), 415-21
[Abstract] [
PDF reprint]
Z Bu and DM Engelman
"A method for determining transmembrane helix associati on and orientation in detergent micelles using small angle X-ray scattering"
Biophys. J. (1999) 77(2), 1064-73
[Abstract] [
PDF reprint]
C Schubert, JA Hirsch, VV Gurevich, DM Engelman, PB Sigler and KG Fleming
"Visual arrestin activity may be regulated by self-asso ciation"
J. Biol. Chem. (1999) 274(30), 21186-90
[Abstract] [
PDF reprint]
S Koide, Z Bu, D Risal, TN Pham, T Nakagawa, A Tamura and DM Engelman
"Multistep denaturation of borrelia burgdorferi OspA, a protein containing a single-layer beta-sheet"
Biochemistry (1999) 38(15), 4757-67
[Abstract] [
PDF reprint]
WP Russ and DM Engelman
"TOXCAT: A measure of transmembrane helix association i n a biological membrane"
PNAS (1999) 96, 863-868
[Abstract] [
PDF reprint]
-----1998-----
DM Engelman"The history of the two-stage model for membrane protei n folding"
(1998): in Cell to brain: the cytoskeleton intra- and inter- cellular communication the central nervous sy stem, Zaccai, G., Massoulie, & David, F., Elsevier, 201-209.
Z Bu, S Koide and DM Engelman
"A solution SAXS study of Borrelia burgdorferi OspA, a protein containing a single-layer beta-sheet"
Protein Science (1998) 7(12), 2681-2683.
[Abstract] [
PDF reprint]
Z Bu, A Perlo, GE Johnson, G Olack, DM Engelman and HW Wyckoff
""A Small-Angle X-ray Scattering Apparatus for Studying Biological Macromolecules in Solution"
J. Appl. Cryst. (1998) 31, 533-543.
[
PDF reprint]
KR MacKenzie and DM Engelman
"Structure-based prediction of the stability of transme mbrane helix-helix interactions: The sequence dependence of glycophorin A dimerization"< BR> PNAS (1998) 95, 3583-3590.
[Abstract] [
PDF reprint]
-----1997-----
JF Hunt, PD McCrea, G Zaccai and DM Engelman"Assessment of the aggregation state of integral membra ne proteins in reconstituted phospholipid vesicles using small angle neutron scattering"
J.Mol.Biol. (1997) 273(5), 1004-1019.
[Abstract] [
PDF reprint]
JF Hunt, P Rath, KJ Rothschild and DM Engelman
"Spontaneous, pH-dependent membrane insertion of a transmembrane alpha-helix"
Biochemistry (1997) 36(49), 15177-15192.
[Abstract] [
PDF reprint]
JF Hunt, O Bousche, TN Earnest, K Kalghatgi, K Reilly, C Horvath, KJ Rothschild and DM Engelman
"A biophysical study of integral membrane protein foldi ng"
Biochemistry (1997) 36(49), 15156-15176.
[Abstract ] [
PDF reprint]
IT Arkin, AT Brunger and DM Engelman
"Are there dominant membrane protein families with a gi ven number of helices?"
Proteins (1997) 28, 465-466.
[
PDF reprint]
CL Burke, MA Lemmon, BA Coren, DM Engelman, and DF Stern
"Dimerization of the p185neu transmembrane domain is ne cessary but not sufficient for transformation"
Oncogene (1997) 14, 687-696.
[Abstract] [
PDF reprint]
KR MacKenzie, JH Prestegard and DM Engelman
"A transmembrane helix dimer: structure and implication s"
Science (1997) 276, 131-133.
[Abstract] [
PDF reprint] [PDB file from RCSB]
IT Arkin, PD Adams, AT Brunger, SO Smith and DM Engelman
"Structural perspectives of phospholamban, a helical tr ansmembrane pentamer"
Ann. Rev. of Biophys. & Biomol. Struc. (1997) 26, 157-179.
[Abstract] [
PDF reprint]
IT Arkin, PD Adams, AT Brunger, S Aimoto, DM Engelman and SO Smith
"Structure of the transmembrane cysteine residues in ph ospholamban"
J. Membrane Biol. (1997) 155(3), 199-206.
[Abstract] [
PDF reprint]
MA Lemmon, Z Bu, JE Ladbury, M Zhou, D Pinchasi, I Lax, DM Engelman and J Schles singer
"Two EGF molecules contribute additively to stabilizati on of the EGFR dimer"
The EMBO J (1997) 16(2), 281-294.
[Abstract] [
PDF reprint]
KG Fleming, AL Ackerman and DM Engelman
"The effect of point mutations on the free energy of tr ansmembrane alpha-helix dimerization"
J Mol Biol. (1997) 272(2), 266-275.
[Abstract] [
PDF reprint]
-----1996-----
DM Engelman"Crossing the hydrophobic barrier: insertion of membran e proteins"
Science, 274 (1996) 1850-1851.
[Abstract]
H Peled-Zehavi, IT Arkin, DM Engelman and Y Shai
"Coassembly of synthetic segments of shaker K+ channel within phospholipid membranes"
Biochemistry (1996) 35, 6828-6838.
[Abstract] [
PDF reprint]
CK Smith, Z Bu, K Anderson, JM Sturtevant, DM Engelman and L Regan
"Surface point mutations that significantly alter the s tructure and stability of a proteins denatured state"
Protein Science (1996) 5, 2009-2019.
[Abstract] [
PDF reprint]
KR MacKenzie, JH Prestegard and DM Engelman
"Leucine sidechain rotamers in a glycophorin A transmem brane peptide as revealed by three bond carbon-carbon couplings and 13C chemical shift"
J. Biomol. NMR (1996) 7, 256-260.
[Abstract]
PD Adams, DM Engelman and AT Brunger
"Improved prediction for the structure of the dimeric t ransmembrane domain of glycophorin A obtained through global searching"
Proteins (1996) 26, 257-261.
[Abstract] [PDB file from RCSB]
CFC Ludlam, IT Arkin, X Liu, MS Rothman, PRath, S Aimoto, SO Smith, DM Engelman and KJ Rothschild
"Fourier transform infrared spectroscopy and site-direc ted isotope labeling as a probe of local secondary structure in the transmembrane domain of phospholamban"
Biophys. J. (1996) 70, 1728-1736.
[Abstract]
KK Rodgers, Z Bu, KG Fleming, DG Schatz, DM Engelman and JE Coleman
"A Zinc-binding domain involved in the dimerization of RAG1"
J. Mol. Biol. (1996) 260, 70-84.
[Abstract] [
PDF reprint]
-----1995-----
IT Arkin, KR MacKenzie, LE Fisher, S Aimoto, DM Engelman and SO Smith"Mapping the lipid exposed surface of membrane proteins by transmembrane sulfhydryl H/D exchange"
Nat. Struc. Biol. (1995) 3, 240-243.
[Abstract]
DM Engelman, BD Adair, AT Brunger, JF Hunt, TW Kahn, MA Lemmon, KR MacKenzie and H Treutlein
"Helix-helix interactions inside membranes"< BR> Biochemistry of Cell Membranes (1995) 297-310.
IT Arkin, M Rothman, CFC Ludlam, S Aimoto, DM Engelman, KJ Rothschild and SO Smi th
"Structural model of the phospholamban ion channel comp lex in phospholipid membranes"
J. Mol. Biol. (1995) 248, 824-834.
[Abstract] [
PDF reprint]
BJ Hare, JH Prestegard and DM Engelman
"Small angle X-ray scattering of magnetically-oriented lipid bilayers"
Biophysical J. (1995) 69, 1891-1896.
[Abstract]
PD Adams, IT Arkin, DM Engelman and AT Brnger
"Computational searching and mutagenesis suggest a stru cture for the pentameric transmembrane domain of phospholamban"
Nat. Struct. Biol. (1995) 2(2), 154-162.
[Abstract] [PDB file from RCSB]
-----1994-----
MA Lemmon and DM Engelman"Specificity and promiscuity in membrane helix interact ions"
FEBS Letters (1994) 346, 17-20.
[Abstract]
IT Arkin, PD Adams, KR MacKenzie, MA Lemmon, AT Brunger and DM Engelman
"Structural organization of the pentameric transmembran e alpha-helices of phospholamban, a cardiac ion channel"
EMBO J. (1994) 13(20), 4757-4764.
[Abstract]
MA Lemmon and DM Engelman
"Specificity and promiscuity in membrane helix interact ions"
Quarterly Rev. of Biophys. (1994) 27, 157-218.
[Abstract]
BD Adair and DM Engelman
"Glycophorin A helical transmembrane domains dimerize i n phospholipid bilayers: a resonance energy transfer study"
Biochemistry (1994) 33(18), 5539-5544.
[ Abstract]
FA Samatey, G Zaccai, DM Engelman, C Etchebest and J-L Popot
"Rotational orientation of transmembrane alpha-helices in bacteriorhodopsin. A neutron diffraction study"
J. Mol. Biol. (1994) 236, 1094-1104.
[Abstract]
M Kataoka,JM Flanagan, F Tokunaga and DM Engelman
"Use of X-ray scattering for protein folding study"
(1994): in Synchrotron Radiation in the Biosciences (B Chance, J Deisenhofer, S Ebashi, DT Goodhead, JR Helliwell, HE Huxley, T Iizuka, J Kirz, T Mitsui, E Rubenstein, N Sakabe, T Sasaki, G Schmahl, HB Stuhrmann, K Wuthrich and G Zaccai, eds.), 187-194, Clarendon Press, Oxford.
-----1993-----
-----1992-----
MA Lemmon, JM Flanagan, HR Treutlein, J Zhang and DM Engelman"Sequence specificity in the dimerization of transmembr ane alpha-helices"
Biochemistry (1992) 31, 12719-25.
[Abstract] [
PDF reprint]